Agmatine is a naturally occurring compound produced in the body from the amino acid L-arginine. It is also found in small amounts in certain fermented foods and has become a popular supplement. Agmatine interacts with several biological pathways, including those involved in nitric oxide production, neurotransmitter activity, and cellular signaling.
Research suggests that agmatine plays a role in supporting normal nervous system function and may influence blood flow, pain signaling, and the body's response to stress.
People commonly use agmatine supplements to support workout performance, enhance muscle pumps by promoting healthy blood flow, and improve exercise recovery. It is also used to support cognitive function, mood, and nerve health, and some individuals take it for discomfort related to nerve pain.