Glucosamine is a chemical found in the body. Glucosamine supplements are sold as glucosamine sulfate, glucosamine hydrochloride, and N-acetyl glucosamine.
Chondroitin sulfate is a chemical found in human and animal cartilage. It is commonly used by mouth with glucosamine or other ingredients for osteoarthritis.
Methylsulfonylmethane (MSM) is a chemical that occurs naturally in humans, as well as some green plants and animals. It can also be made in a lab.
Glucosamine is used by the body to make other chemicals that build tendons, ligaments, cartilage, and the fluid that surrounds joints. Joints are cushioned by the fluid and cartilage around them. Taking glucosamine might increase the cartilage and fluid around joints and/or help prevent their breakdown.
Chondroitin sulfate is one of the building blocks of cartilage. In osteoarthritis, the cartilage in the joints breaks down. Taking chondroitin sulfate might slow this breakdown. It is usually manufactured from animal sources, such as shark and cow cartilage. It can also be made in a lab.
MSM might supply sulfur to make other chemicals in the body. But there is no recommended dietary allowance (RDA) for MSM or sulfur, and sulfur deficiency is not a known condition.
People commonly use glucosamine sulfate and glucosamine hydrochloride for osteoarthritis. Glucosamine is also used for joint pain, rheumatoid arthritis, multiple sclerosis, and many other conditions.
Chondroitin sulfate is used for osteoarthritis and cataracts. It is often used together with other ingredients, including manganese ascorbate, hyaluronic acid, collagen peptides, or glucosamine. Chondroitin sulfate is also used for many other conditions.
People commonly use MSM for osteoarthritis. It is also used for pain, swelling, aging skin, hay fever, and many other conditions.
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