Hydroxymethylbutyrate (HMB) is a chemical that is made when the body breaks down leucine. Leucine is an amino acid, one of the building blocks of protein.
HMB might promote muscle growth. It can be found naturally in small amounts in grapefruit, alfalfa, and catfish. It's also naturally made in the body.
People use HMB for building muscle or preventing age-related muscle loss. It's also used for athletic performance, muscle loss due to HIV/AIDS, muscle strength, obesity, and many other purposes.
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